Copyright 2003 Osaka University. All Right Reserved.Integrated functional analyses of disease-associated sugar chains and proteins, Osaka University
|One of the most important fields of research
at the post-genomic era is identification and characterization
of the function of sugar chains in addition to characterization
of protein functions. There are growing evidence that the sugar
chains play a pivotal role in the protein function. In fact over
50 % of proteins are expected to undergo glycosylation and modification
by sugar chains, i.e., glycosylation is the most common posttranslational
modification of proteins. Thus, sugar chains confer different
properties independent from Central dogma.
Moreover sugar chains greatly contribute to the life processes
both in functionality and universality.
The aim of this COE is to investigate the role and relationship
between the life-style associated diseases including degenerative
nerve diseases, protein folding diseases, cancer, hepatitis, diabetes
and fatty liver which are socially requisite, and disorders associated
with organelles such as the endoplasmic reticulum, mitochondria,
Golgi apparatus and cell membranes etc. In addition the long-term
goal is to develop epoch-making glyco-drugs and protein drugs
against above diseases. In order to accomplish these goals, it
is requisite to interdisciplinary research and acquire knowledge
with a highly standard and techniques and accomplishments. This
COE is comprised of 10 core members who are experts and internationally
renowned scientists in this field and covers fields of expertise
in biochemistry, molecular biology, developmental technology,
human genetics, cell biology, neuroscience, immunology and hematology.
In addition, we also include scientists with expertise in sugar
chain analysis and mass spectrometry and we are confident that
this COE will be able to characterize the functions of sugar chains.
Future studies include cooperative research on sugar chains and
protein research and will bring together other fields of research.
The goal is to integrate those accomplishments and develop a filed
of Systems Medical Biology. It is essential for us
to make every effort to collaborate with scientists in various
fields in order to succeed in characterizing and identifying the
cause of various non-curable diseases and develop an appropriate
The Osaka University Graduate School of Medicine/ Medical School
has successfully established for the first time basic laboratory
training course in laboratory for medical students and entrance
systems that are open to students with the bachelor degree and
also have developed an MD/PhD program, and moreover introduced
graduate school system which is affiliated with several research
institutions. Moreover in 2003, we introduced an endowed department
designated as the Department of Glycotherapeutics and Research
Center for Systems Glycobiology.
By utilizing the above activities, we plan to develop an international
COE in medical science based on the Osaka university motto
Live locally live globally in collaboration with local medical
facilities and industries. In some specific programs, we will
support students in an MD/PhD program, graduate students, the
introduction of specially recognized assistant and associate professorships,
an endowed professorship with an excellent scientific achievement
named after Dr. Ogata Koan, support the A-IMBIN- AMBO International
Training Course for young scientists from Asian and Oceanic countries
and also support for day care centers for children.
Through the above plans, we will be able to establish a unique
COE in medical science.