|
|
|
|
|
|
Integrated
functional analyses of disease-associated sugar chains and proteins
One of the most important biomedical goals
of science in the post-genomic era is to identify
the functional properties of proteins and
elucidate the cause and treatment of human
diseases. Over 50 % of proteins undergo glycosylation
but the precise function of the sugar chains
continues to be a subject of study. In fact,
glycosylation occurs most frequently among
the post-translational modifications of proteins.
There are three groups with ten core members
and encompasses, and those three groups focus
on 1) functional analyses of disease-associated
sugar chains and proteins in vitro and in
vivo, 2) functional disorders of organelles
such as the endoplasmic reticulum, Golgi apparatus
and mitochondria that are involved in nerve
degenerative diseases such as Alzheimer's
disease, amyotrophic lateral sclerosis, cancer
and life-style associated diseases as well
as hepatitis, 3) the development of high-through
put analyses and ultra-micro analyses for
sugar chains and proteins such as glycoproteomics
which is an important part of our work (see
Figure). In this program, core
members are mostly from Osaka University
Medical School, partly from Osaka Medical
Center for Cancer and Cardiovascular Diseases,
and Osaka Medical Center and Research Institute
for Maternal and Child Health both of which
participate jointly in a graduate school program.
We intend to characterize the causes and mechanisms
of the above diseases in this research project
which have not been clarified by previous
approaches and create a novel and unique Center
of Excellence (COE).
The COE encourages young scientists and graduate students who
wish to participate in future biomedical sciences. An MD/PhD
program is already in place, which is designed for the education
and training of exceptionally highly qualified individuals who
want to pursue careers in biomedical sciences. We will financially
support MD/PhD candidates, as well as graduate students as research
associates. We also plan to create an endowed professorship
designated as the Dr. Koan Ogata Professorship, named after
the great educator and scholar who introduced medical science
from the Netherlands into Japan at the end of the Edo period
and opened his private school, Tekijuku, in Osaka. Moreover,
we plan to invite an excellent, internationally renowned scientist
in this field to participate in research projects and interact
with postdoctoral fellows. Lastly, we will provide partial subsidies
to graduate students, faculty and staff to defray a portion
of their expenses at the day care centers inside the campus
which will be collaborated with the university.
The goals of the COE program are to pursue
creative and innovative research in this field
and integrate glycobiology with systems glycobiology
and explore the role of sugar chains in biological
systems in the 21st century. We also plan
to provide an optimal environment for education
and research which utilizes the individual
talents of participating faculty and students
leading to a great understanding of the cause
and treatment of human diseases. Our overall
goal of this COE program is to become a "center
of world caliber" in the 21st century
by fulfilling Osaka University's motto "Live
Locally, Grow Globally".
|
|
|
| PAGE TOP |
Copyright 2003 Osaka University. All Right Reserved.
Integrated functional analyses of disease-associated sugar chains and proteins, Osaka University
|
|
|
|
|