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The
aim of this project (the most important items)
Integrative studies will be performed on the
identification and characterization of the
function of disease-associated sugar chains
and proteins and the characterization of disorders
of organelles and establish a “center
of excellence” in the 21 st century,
in terms of research and education which may
link to the development of epoch-making diagnostic
tools and therapeutics of the above diseases.
(Integrated research on glycobiology and disease-associated
proteins)
Characteristics
and future perspectives
The project is comprised of three axes.
1) Functional analyses of disease-associated
sugar chains and proteins and the development
of therapeutic strategies:
Cancer invasion and metastasis, the structure
of skeletal muscle, the growth and development,
characterization of sugar chains and proteins,
and the development of diagnostic tools and
their therapy.
2) Functional disorder of organelles such
as, the endoplasmic reticulum, mitochondria,
Golgi apparatus and cell membrane which may
cause cancer, life-style associated diseases
(metabolic disease, atherosclerosis), nerve
degenerative diseases (Alzheimer disease,
Parkinson’s disease, Shizophrenia, amyotrophic
lateral sclerosis and hepatitis etc), and
their therapeutic approach.
3) Development of high though put analyses
of sugar chains and proteins:
ultra-micronalyses of sugar chains and proteins,
high through put proteomics and glycomics,
visible technology, sugar remodeling technology,
development of downsizing and versatile equipment.
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Copyright 2003 Osaka University. All Right Reserved.
Integrated functional analyses of disease-associated sugar chains and proteins, Osaka University
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