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The aim of this project (the most important items)

Integrative studies will be performed on the identification and characterization of the function of disease-associated sugar chains and proteins and the characterization of disorders of organelles and establish a “center of excellence” in the 21 st century, in terms of research and education which may link to the development of epoch-making diagnostic tools and therapeutics of the above diseases.

(Integrated research on glycobiology and disease-associated proteins)

Characteristics and future perspectives

The project is comprised of three axes.
1) Functional analyses of disease-associated sugar chains and proteins and the development of therapeutic strategies:
Cancer invasion and metastasis, the structure of skeletal muscle, the growth and development, characterization of sugar chains and proteins, and the development of diagnostic tools and their therapy.
2) Functional disorder of organelles such as, the endoplasmic reticulum, mitochondria, Golgi apparatus and cell membrane which may cause cancer, life-style associated diseases (metabolic disease, atherosclerosis), nerve degenerative diseases (Alzheimer disease, Parkinson’s disease, Shizophrenia, amyotrophic lateral sclerosis and hepatitis etc), and their therapeutic approach.
3) Development of high though put analyses of sugar chains and proteins:
ultra-micronalyses of sugar chains and proteins, high through put proteomics and glycomics, visible technology, sugar remodeling technology, development of downsizing and versatile equipment.


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Integrated functional analyses of disease-associated sugar chains and proteins, Osaka University